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Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs.
Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA.
Expert Opin Investig Drugs. 2008 Feb;17(2):197-208. Review.
18230053 [Abstract]

Therapeutic vaccination against malignant gliomas based on allorecognition and syngeneic tumor antigens: Proof of principle in two strains of rat.
Stathopoulos A, Samuelson C, Milbouw G, Hermanne JP, Schijns VE, Chen TC.
Vaccine. 2008 Mar 25;26(14):1764-72.
18336964 [Abstract]

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.
Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH.
Cancer Res. 2008 Feb 1;68(3):843-51.
18245486 [Abstract]

Management of brain metastasis:  neurosurgical considerations.
Chen TC  
Oncology 21: 484-489, 2007.

HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.
Pyrko P, Kardosh A, Wang W, Xiong W, Schönthal AH, Chen TC.
Cancer Res. 2007 Nov 15;67(22):10920-8.
18006837 [Abstract]

Primary intraosseous meningioma.
Elder JB, Atkinson R, Zee CS, Chen TC.
Neurosurg Focus. 2007;23(4):E13. Review.
17961037 [Abstract]

Nelfinavir potentiation of imatinib cytotoxicity in meningioma cells via survivin inhibition.
Gupta V, Samuleson CG, Su S, Chen TC.
Neurosurg Focus. 2007;23(4):E9.
17961046 [Abstract]

Calcium activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.
Pyrko P, Kardosh A, Liu YT, Soriano N, Xiong W, Chow RH, Uddin J, Pestasis NA, Mircheff AK, Farley RA, Louie SG, Chen TC, Schonthal AH.
Mol Cancer Ther 6(4): 1262-75, 2007.

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Pyrko P, Schönthal AH, Hofman FM, Chen TC, Lee AS.
Cancer Res. 2007 Oct 15;67(20):9809-16.
17942911 [Abstract]

Efficacy of celecoxib in the treatment of CNS lymphomas: an in vivo model.
Wang W, Kardosh A, Su YS, Schonthal AH, Chen TC.
Neurosurg Focus. 2006 Nov 15;21(5):E14.
17134116 [Abstract]

Surgical Considerations in CNS Lymphomas.
Elder JB, Chen TC
Neurosurg Focus 21(5):E13, 2006.

Introduction to Primary Central Nervous System Lymphomas.
Chen TC, Abrey LN.
Neurosurg Focus 21(5):  Intro, 2006.

Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.
Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen CS, Chen TC, Schonthal AH. 
Mol Cancer 5(1):19, 2006.
16707021 [Abstract]

Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration.
Milan J, Charalambous C, Elhag R, Chen TC, Li W, Guan S, Hofman FM, Zidovetzki R.
Am J Physiol Cel Physol 291 (1): C155-64, 2006.
16452160 [Abstract]

Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells.
Gupta V, Wang W, Sosnowski BA, Hofman FM, Chen TC.
Neurosurg Focus. 2006 Apr 15;20(4):E26.
16709032 [Abstract]

Use of replication competent retroviral vectors in an immunocompetent intracranial glioma model.
Wang W, Tai CK, Kershaw A, Solly SK, Klatzmann D, Kasahara N, Chen TC.
Neurosurg Focus 20 (4), 2006.
16709031 [Abstract]

Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Neurosurg Focus. 2006 Apr 15;20(4):E20.
Gupta V, Su YS, Wang W, Kardosh A, Liebes LF, Hofman FM, Schönthal AH, Chen TC.
16709026 [Abstract]

Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy.
Wang W, Zhu NL, Chua J, Swenson S, Costa FK, Schmitmeier S, Sosnowski BA, Shichinohe T, Kasahara N, Chen TC.
J Neurosurg. 2005 Dec;103(6):1058-66.
16381193 [Abstract]

Multi-target inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib.
Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC Schonthal AH.
Blood 106:4330-4338, 2005.

Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma.
Tai CK, Wang WJ, Chen TC, Kasahara N.
Mol Ther. 2005 Nov;12(5):842-51.
16257382 [Abstract]

The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model.
Pyrko P, Wang W, Markland FS, Swenson SD, Schmitmeier S, Schönthal AH, Chen TC.
J Neurosurg. 2005 Sep;103(3):526-37.
16235686 [Abstract]

Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin.
Schmitmeier S, Markland FS, Schönthal AH, Chen TC.
Neurosurgery. 2005 Jul;57(1):141-53; discussion 141-53.
15987550 [Abstract]

Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.
Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH.
Cancer Biol Ther. 2005 May;4(5):571-82. Epub 2005 May 5.
15846081 [Abstract]

Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells.
Charalambous C, Hofman FM, Chen TC.
J Neurosurg. 2005 Apr;102(4):699-705.
15871513 [Abstract]

Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro.
Schmitmeier S, Markland FS, Ritter MR, Sawcer DE, Chen TC.
Cell Commun Adhes. 2003 Jan-Feb;10(1):1-16.
12881036 [Abstract]

Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Chen TC, Su S, Fry D, Liebes L.
Cancer. 2003 May 1;97(9 Suppl):2363-73.
12712458 [Abstract]